For instance, approximately 25–30% of HIV patients with Cn infections develop IRIS within the first four months of ART, with an average mortality rate of 8–30% 11. Thus, the incidence of C-IRIS is frequently reported. Cn infections and CM are common in human immunodeficiency virus (HIV) patients receiving antiretroviral therapy (ART), whose immune systems, particularly T cells, undergo reconstitution 10. These symptoms typically have a subacute onset, although acute and chronic onsets can also be observed 9. In addition, non-neurological presentation, including lymphadenopathy and pulmonary disease, can occur in C-IRIS patients 3, 4, 5, 6, 7, 8. Clinical presentations of C-IRIS include headache, fever, cranial neuropathy, alteration of consciousness, lethargy, memory loss, meningeal irritation signs, and visual disturbance 2. C-IRIS is a common manifestation of cryptococcal meningitis (CM) and is characterized by central nervous system (CNS) complications 1. Cryptococcus-associated immune reconstitution inflammatory syndrome (C-IRIS) is a condition that occurs when a patient infected with Cryptococcus neoformans (Cn) has an overactive immune system during reconstitution, endangering their life 1.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |